Process of producing vitamine preparations



25 conditions as to avoid appreciable hydroly- Patented June 4, 1929.

IT D STATES PATENT OFFICE.

AAGE WILLAND own, or osLo, NORWAY.

PROCESS OF PRODUCING VITAMINE PREPARATIONS. I

No Drawing. Application filed March 11, 1926, Serial No. 94,033, and inNorway October 11, 1924.

I have filed applications in Norway Oct. 11, 1924, Ser. No. 31,586, andin Germany Nov. 3, 1924, Ser. No. 14561.

This invention relates to the production of vitamine preparations bysaponifying vitamine bearing marine fats and subsequently extracting ereaction mass with edible fat and the most important characteristicfeature of the invention consists therein that the extraction withedible fat takes place in the absence of wateror in the presence of suchsmall proportions of water that the soaps will not be appreciablyhydrolyzed.

In the hitherto known methods of extracting soaps richin vitamines withedible fats the soaps are in aqueous solution. As a consequence of thisthe reaction operation involves the formation of a very persistentemulsion which renders it diflicult to'sepa! rate the fat extractwithout taking up considerable proportions of soap.

As compared with these known processes .the present invention ischaracterized therein that the extraction takes place under such zationof the soaps. Thisinvolves the advantage, that after the extractionoperation the oil can be separated in an entirely clear [condition sothat it can be used directly or after a quite simple purificationtreatment as component of medicine or food. In order to obtain that thesoaps are in an undissociated condition during theextraction operationone may for example take care that the saponification is effected bymeans of a saponification agent (alkali or alkaline earth which is freefrom or substantially free om water. The fats may for example beconverted into lime soaps by sapon'ifylng 40 with calcium hydroxide.Whenthis'saponification treatment is carried into efiect inasuitablemanner a solid mass results which excluded during the operation becausethe It is o importance in order.

vitamines would otherwise readily become destroyed.

Example.

1,4 kg. of caustic lime is slaked with Water-somewhat in excess of thetheoretical quant1ty (for example about 1 liter).

10 kg. of fish liver oil is heated in an inert gas atmosphere to 100 C.whereupon the slaked lime is introduced in small portions and mixed withthe oil by stirring.

-The, resulting mass is left standing for 18 to 20 hours in a vesselwhich is properly insulated against losses of heat.

After this time has lapsed the reaction is completed. The resultingsolid calcium soap is ground to a powder, which'is thereupon digestedwith 20 kg. of cotton oil at 4050 C. during 20-24 hours. After coolingthe .oil is separated from the remaining solid residue by -filtration.The resulting oil is clear and contains a great proportion of thevitamines of the initial material.

I claim:

1. The process of. producing vitamine a vitamine containing fat with analkaline earthmetal hydroxide to form a waterinsoluble metal soap,pulverizing the soap, and extracting the. vitamines from thepulverpreparations which'comprises saponifying ized soap with an ediblefat. to form an edible fat containing vitamines.

2. The process as in claim 1 in which the lime.

alkaline earth metal hydroxide is slaked 3. The process of producingvitamine preparations which comprises saponifying a vitamine containinfat with an'alkaline earth metal hydroxide to form a water insolublemetal soap, lixiviating the resultin solid soap product with an ediblefat an thereafter separating the resulting vita1n-- inized edible fatfrom the remaining solid soap product.

4. Process according to claim 3 in whic the alkaline metal hydroxide isslaked lime.

In testimony whereof I have signed my name to this specification.

AAGE VVILLAND OWE.

